50 下列何者為α1 -antagonist，同時具有較弱α2 -agonist 及5-HT 1A -agonist 作用，可用於治療高血壓及良性前列腺增生病人？
(A) Phenylephrine
(B) Metoprolol
(C) Urapidil
(D) Metaproterenol

(D)Metaproterenol是β-agonist用於治療氣喘。

快速解法

症狀   看到治療高血壓先把(A)去掉

然後看分類  為a的antagonist  B和D就可以去掉了   答案C

Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. 

Urapidil主要阻斷α1,兼具弱β1阻斷
同時也具微弱的α2、5-HT1A致效作用