50.下列關於HIV(Human immunodeficiency virus)的敘述,何者錯誤?
(A)M-tropic病毒會利用CXCR4當作其細胞的受器之一
(B)T-tropic病毒通常會隨著病人病程的進展而增加
(C)Kaposi’s sarcoma是常見於愛滋病人的癌症
(D)CD4 T細胞數目降至200/µL 以下,易出現伺機性感染
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統計: A(160), B(116), C(19), D(13), E(0) #1324547
統計: A(160), B(116), C(19), D(13), E(0) #1324547
詳解 (共 3 筆)
#4034086
POL (產生:reverse transcriptase)
ENV (產生: envelope) 變異性大>因為不斷突變
HIV 病毒利用 receptor-mediated endocytosis 進入細胞,使用的主要 receptor 是 CD4,co-receptor 分
成兩類,
M(Macrophage)-tropic strain 是 CCR5(此 tropism 又稱 R5),
T(T cell)-tropic strain 才是CXCR4(此 tropism 又稱 X4)
(A)M-tropic病毒會利用CXCR4當作其細胞的受器之一
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#2344194
T-tropic才是CXCR4
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#2891922
The co-receptor used upon initial infection by HIV is CCR5, which is expressed on myeloid and peripheral, activated, central memory, intestinal, and other subsets of CD4 T cells (macrophages, [M]-tropic virus). Later, during chronic infection of a person, the env gene mutates so that the gp120 binds to a different chemokine receptor (CXCR4), which is expressed primarily on T cells (T-tropic virus)
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