專技 - 調劑學與臨床藥學題庫下載題庫

 Serum itraconazole and ketoconazole concentrations were reduced as much as 90% (often to undetectable values) in patients also receiving rifampin (plus isoniazid in some), and disease relapses have been reported.1,2,3,4,5,6 Rifampin (600mg daily) reduced voriconazole maximum plasma concentration (Cmax) by 93% and AUC by 96% when administered together with voriconazole (200mg every 12 hours) in healthy subjects.7 Rifabutin (300mg daily) had a similar effect when combined with voriconazole, reducing Cmax by 69% and AUC by 78%.7Fluconazole (200mg daily) AUC was decreased an average of 23% aft...

 Serum itraconazole and ketoconazole concentrations were reduced as much as 90% (often to undetectable values) in patients also receiving rifampin (plus isoniazid in some), and disease relapses have been reported.1,2,3,4,5,6 Rifampin (600mg daily) reduced voriconazole maximum plasma concentration (Cmax) by 93% and AUC by 96% when administered together with voriconazole (200mg every 12 hours) in healthy subjects.7 Rifabutin (300mg daily) had a similar effect when combined with voriconazole, reducing Cmax by 69% and AUC by 78%.7Fluconazole (200mg daily) AUC was decreased an average of 23% after 15 days of rifampin (600mg daily) in 8 healthy volunteers.8 The mechanism of these interactions is likely CYP3A4 isoenzyme induction by rifampin leading to increased azole metabolism.

The serum concentrations of cyclosporine can be reduced to grossly subtherapeutic values, permitting acute graft rejection, following the addition of rifampin therapy