61.下列那一藥物注射給藥後對腦脊髓液之穿透力最好？
(A)cephalexin
(B)aztreonem
(C)gentamicin
(D)azithromycin

補充一下，Azithromycin是屬於巨環類抗生素，脂溶性好，能穿透BBB，進到腦組織，但不會進到腦脊髓液。

“azithromycin appears to be widely distributed into brain tissue but not into cerebrospinal fluid or aqueous humor of the eye.”

"Azithromycin is well absorbed. It reaches high and sustained tissue concentrations and penetrates the blood-brain and blood-ocular barriers when they are inflamed."

Reference:

Jaruratanasirikul, S., R. Hortiwakul, T. Tantisarasart, N. Phuenpathom, and S. Tussanasunthornwong. 1996. Distribution of azithromycin into brain tissue, cerebrospinal fluid, and aqueous humor of the eye. Antimicrob. Agents Chemother. 40:825-826.

Hammami, Fatma & Fourati, Salma & Koubaa, Makram & Smaoui, F. & Rekik, Khaoula & Marrakchi, Ch & Jemma, Mounir. (2020). Azithromycin-Related Bicytopenia: An Exceptional Adverse Effect. Journal of Pharmaceutical Care. 7. 10.18502/jpc.v7i4.2381.