試題詳解

61. 以下關於 microsatellite instability-high (MSI-H) 子宮內膜癌的描述，何者為非？
(A) Mutations in or epigenetic silencing of mismatch repair genes leading to genomic instability and high burden of somatic mutations.
(B)Associated with mutations that upregulate signaling through the PI3K/AKT pathway.
(C)Prevalent in endometrial carcinomas arising in women with hereditary nonpolyposis colorectal carcinoma syndrome (also referred to as Lynch syndrome).
(D)In sporadic endometrioid carcinoma, loss of DNA mismatch repair gene is commonly caused by epigenetic silencing.