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GABA-A antagonist:Bicuculline,Picrotoxin

 a number of compounds can bind to the GABAA receptor and antagonize the actions of GABA.

Bicuculline, by binding to the GABA recognition site and preventing GABA from binding, produces convulsions in experimental animals .

Picrotoxin, via its active metabolite picrotoxinin binds in the Cl-channel to prevent ion flow when the receptor is activated by GABA.Picrotoxin does not alter GABA binding, but instead prevents ion sfrom flowing and is a potent convulsant.

Beclofen:GABA-B agonist

Muscimol:GABA-A agonist
2-hydroxy-s-SaclofenGABA-B antagonis...

GABA-A antagonist:Bicuculline,Picrotoxin

 a number of compounds can bind to the GABAA receptor and antagonize the actions of GABA.

Bicuculline, by binding to the GABA recognition site and preventing GABA from binding, produces convulsions in experimental animals .

Picrotoxin, via its active metabolite picrotoxinin binds in the Cl-channel to prevent ion flow when the receptor is activated by GABA.Picrotoxin does not alter GABA binding, but instead prevents ion sfrom flowing and is a potent convulsant.

Beclofen:GABA-B agonist

Muscimol:GABA-A agonist
2-hydroxy-s-SaclofenGABA-B antagonist