畢竟cimetidine不過就是個制酸劑
phenytoin可是抗癲癇藥,副作用多的多,也嚴重得多,還需要TDM
micromedex
inhibition of 2C19-mediated phenytoin metabolism
Concurrent use of CIMETIDINE and PHENYTOIN may result in an increased risk of phenytoin toxicity (ataxia, hyperreflexia, nystagmus, tremor)
抑制作用比誘導作用先發生
cimetidine為CYP2C19 weak inhibitor,但不是CYP受質
phenytoin為CYP3A4 inducer,且為CYP2C9、2C19受質
70.併用cimetidine與phenytoin產生交互作用時,最主要的原因為..-阿摩線上測驗