82.下列有關V[D]J recombination的敘述,何者錯誤?
(A)參與抗體多樣性的生成
(B)其反應機制與同源重組(homologous recombination)相似
(C)recombination activating gene 1(RAG1)參與作用
(D)recombination activating gene 2(RAG2)參與作用
統計: A(34), B(470), C(44), D(83), E(0) #1740763
詳解 (共 3 筆)
同源重組(Homologous recombination)是遺傳重組的一種類型,指兩股具有相似序列的DNA的重新排列,使遺傳物質發生交換。
recombination-activating genes (RAGs) 對於 免疫球蛋白和T細胞受體分子的基因的重排和重組作用 佔有一定腳色。
有兩個激活重組的基因RAG1和RAG2,在其發育階段其細胞表達僅限於淋巴球。
由這些基因編碼的酶,RAG-1和RAG-2,是成熟的B細胞和T細胞,兩種類型的淋巴細胞是適應性免疫系統的關鍵成分的生成是必不可少的。
The recombination-activating genes (RAGs) encode parts of a protein complex that plays important roles in the rearrangement and recombination of the genes encoding immunoglobulin and T cell receptor molecules. There are two recombination-activating genes RAG1 and RAG2, whose cellular expression is restricted to lymphocytes during their developmental stages. The enzymes encoded by these genes, RAG-1 and RAG-2, are essential to the generation of mature B cells and T cells, two types of lymphocyte that are crucial components of the adaptive immune system.