84 下列何者不是惡性腫瘤必須具有的生理特性？
(A) Insensitivity to anti-growth signals
(B) Sustained angiogenesis
(C) Evasion of apoptosis
(D) Active mitotic activity

Certain fundamental changes in cell physiology contribute to development of the malignant phenotype:

• Self-sufficiency in growth signals (proliferation without external stimuli)

• Insensitivity to growth-inhibitory signals

• Evasion of apoptosis

• Defects in DNA repair

• Limitless replicative potential (related to telomere maintenance)

• Sustained angiogenesis to provide adequate nutrition and waste removal

• Ability to invade and metastasize

• Ability to escape immune recognition and regulation