85 下列有關 t（15;17）細胞遺傳變異的敘述，何者錯誤？
(A)此變異涉及 RAR-α（retinoic acid receptor-alpha）及 PML 基因
(B)幾乎全發生於 M3 型急性髓球性白血病病人
(C)使用 ATRA 全反式視黃酸（all-trans retinoic acid）治療，可獲緩解
(D)較少見奧爾氏桿（Auer rods）

答案：登入後查看
統計： A(4), B(24), C(9), D(80), E(0) #828230

詳解 (共 2 筆)

#2886006

0-14 = ALL 

15-39 = AML – myeloblast with Auer rods in peripheral blood

acute progranulocytic anemia (M3) – they always have DIC, has a translocation 15,17.  Rx = retinoic acid (vit A – causes blasts to mature into b9 cells).

40-59 AML, CML (separate with BM – AML with >30% and CML with <30%, 9, 22, Philly c’some)

60+ = CLL

MC overall leukemia regardless of age = CLL

MCC generalized nontender lymphadenopathy in pt 60+ = CLL; not b/c it’s a lymphoma, but b/c it mets to lymph nodes).

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