72.Fluoroquinolones藥物第七碳位置上的piperazine環,..-阿摩線上測驗
3F Heng 大一上 (2019/06/11)
Figure 37.1 shows the basic quinolone structure. The carboxyl group at position 3 and the ketone at position 4 are necessary for the antibacterial activity. The fluorine at position 6 differentiates the quinolones from the fluoroquinolones and accounts for the improved gram-negative and gram-positive activity over the nonfluorinated quinolones, increased potency, and increased entry into bacteria. At position 1, addition of a cyclopropyl (as for enrofloxacin and ciprofloxacin), an ethyl or a fluorophenyl improve the spectrum of activity against gram-positive and gram-negative bacteria. Additio... 查看完整內容 |
4F 獸醫國考整理與口訣 IG: 高三上 (2022/10/02)
課本954頁有提及 第7碳位置上增添piperazine環之後具有提升抗菌能力之廣泛度 尤其是包含pseudomonads在內的格蘭氏陰性菌們
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