獸醫藥理學題庫下載題庫

 ketoprofen is a cyclo-oxygenase (Cox-1 and -2) inhibitor that blocks the formation of prostaglandins that are important in pain and inflammatory pathways. 

Naproxen (brand names: Aleve, Naprosyn, and many others) is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same class as ibuprofen) that relieves pain, fever, swelling, and stiffness.^[6][7] It is a nonselective COX inhibitor, usually sold as the sodium salt. It is available in both an immediate release and extended release formulation. Naproxen is generally safe to use in breastfeeding mothers.

(A)acetaminophen

The mechanism of action of paracetamol is not completely understood. Unlike NSAIDs such as aspirin, paracetamol does not appear to inhibit the function of any cyclooxygenase (COX) enzyme outside the central nervous system, and this appears to be the reason why it is not useful as an anti-inflammatory.^[102] It does appear to selectively inhibit COX activities in the brain, which may contribute to its ability to treat fever and pain.^[102] This activity does not appear to be direct inhibition by blocking an active site, but rather by reducing COX, which must be oxidized in order to function.^[102]

It also appears that paracetamol might modulate the endogenous cannabinoid system in the brain through paracetamol's metabolite, AM404. AM404 appears to inhibit the reuptake of the endogenous cannabinoid/vanilloid anandamide by neurons, making it more available to reduce pain. AM404 also appears to be able to directly activate the TRPV1 (older name: vanilloid receptor), which also inhibits pain signals in the brain

meclofemic acid 

藥理作用

Mefenamic acid是一種非類固醇抗發炎藥(NSAID)，在實驗動物體內具有抗發炎、止痛及退燒等作用。動物模式研究發現，mefenamic acid會抑制前列腺素的合成，並在前列腺受體部分結合。