專技 - 藥物治療學題庫下載題庫

Basic two-drug postexposure prophylaxis(PEP) is generally recommended for less severe percutaneous exposures (solid needle or superficial injury) from an HIV-positive patient who is suppressed on antiretrovirals, a patient with an unknownHIV statuswho has HIV risk factors, or formucous membrane exposures. Basic two-drug PEP generally consists of two NRTIs such as zidovudine, stavudine, or tenofovir with lamivudine or emtricitabine.

Expanded three-drug PEP is recommended for more severe percutaneous exposures (large-bore hollow needle or deep puncture wound) from suppressed HIV-positive patients...

Basic two-drug postexposure prophylaxis(PEP) is generally recommended for less severe percutaneous exposures (solid needle or superficial injury) from an HIV-positive patient who is suppressed on antiretrovirals, a patient with an unknownHIV statuswho has HIV risk factors, or formucous membrane exposures. Basic two-drug PEP generally consists of two NRTIs such as zidovudine, stavudine, or tenofovir with lamivudine or emtricitabine.

Expanded three-drug PEP is recommended for more severe percutaneous exposures (large-bore hollow needle or deep puncture wound) from suppressed HIV-positive patients and more-than-three–drug PEP is indicated for percutaneous exposures where the patient has a high viral load or acute infection or from similar patients if there is a large volume mucous membrane exposure. In these instances, the choice of agents to use for PEPis generally dependent on the patient’s regimen and resistant profile. expanded basic regimen of at least three drugs consisting of two of the NNRTIs recommended for basic two-drug PEP with the addition of a PI, preferably lopinavir–ritonavir.This entire regimen should be continued for a total of 4 weeks.