專技 - 藥物治療學題庫下載題庫

The clearance of theophylline was decreased by 16% to 21% in healthy volunteers following the initiation of isoniazid therapy.1,2 A 31% increase in theophylline AUC was noted in another study.3 Cases of theophylline toxicity associated with this interaction have been reported.4,5

The likely primary mechanism of this interaction is isoniazid inhibition of CYP3A4 mediated theophylline metabolism. Isoniazid inhibition of CYP1A2 mediated theophylline metabolism may also contribute...

The clearance of theophylline was decreased by 16% to 21% in healthy volunteers following the initiation of isoniazid therapy.1,2 A 31% increase in theophylline AUC was noted in another study.3 Cases of theophylline toxicity associated with this interaction have been reported.4,5

The likely primary mechanism of this interaction is isoniazid inhibition of CYP3A4 mediated theophylline metabolism. Isoniazid inhibition of CYP1A2 mediated theophylline metabolism may also contribute.