(a) How does inhibitor bind enzyme? (do they compete the same site with the substrate, or substrate and inhibitor bind different sites, or inhibitor binds the enzyme only when substrate binds the enzyme) (4%)

4. The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza "for their discoveries of how cells sense and adapt to oxygen availability."When oxygen is limited, hypoxic stress triggers the expression of hypoxia inducible factor (HIF) protein in mammalian tissues. Briefly describe the function of HIF-1 and how it affects the rate of glycolysis under hypoxia.

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(a) How does inhibitor bind enzyme? (do they compete the same site with the substrate, or substrate and inhibitor bind different sites, or inhibitor binds the enzyme only when substrate binds the enzyme) (4%)

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