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28. Epigenetic modulation can control gene expression without changing DNA
sequences. Please explain how this is achieved (5 points).
27. The two strands of DNA double helix can be separated by heating. If you raised the temperature of a solution containing the following three DNA molecules, in what order do you suppose they would "melt"? Explain your answer (10 points).

【題組】
C. 5'-AGAGCTAGATCGAT-3'
3'-TCTCGATCTAGCTA-5'
【題組】
B. 5'-ATTATAAAATATTTAGATACTATATTTACAA-3'
3'-TAATATTTTATAAATCTATGATATAAATGTT-5'
40. 2',3'-dideoxycytidine (ddC), can serve as a drug for HIV infections because of the absence of a
group which is required for
(A) 2'-hydroxyl; transcription
(B) 3'-hydroxyl; replicative chain elongation
(C) 5'-hydroxyl; translation
(D) 2'-hydroxyl; replicative chain elongation
39. Which enzyme is defective in patients with maple syrup urine disease?
(A) branched-chain a-amino acid aminotransferase
(B) branched-chain a-amino acid dehydrogenase
(C) branched-chain a-keto acid dehydrogenase
(D) branched-chain a-keto acid decarboxylase
38. Which symptom is a consequence of vitamin B12 deficiency?
(A) anemia
(B) homocysteinemia
(C) neurological disorder
(D) all of the above

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