105. A 45-year-old male stomach cancer patient underwent tumor removal surgery. After surgery, he
developed megaloblastic anemia. His anemia is caused by a deficiency of X and can be treated
with Y.
(A)X = intrinsic factor； Y = folic acid.
(B)X = intrinsic factor； Y = vitamin B12
(C)X = extrinsic factor； Y = parenteral iron
(D)X = extrinsic factor； Y = sargramostim
106. Which of the following drugs has a high affinity for 5-HT2 receptors in the brain, does not cause
extrapyramidal dysfunction or hematotoxicity, but is reported to increase the risk of significant
QT prolongation?
(A)Clozapine
(B)Haloperidol
(C)Valproic acid
(D)Ziprasidone
107. A 40-year-old woman has sporadic attacks of intense anxiety with marked physical symptoms,
including hyperventilation, tachycardia, and sweating. If she is diagnosed as suffering from a
panic disorder, the most appropriate drug to use is
(A)Alprazolam
(B)Eszopiclone
(C)Flurazepam
(D)Ramelteon
108. A 62-year-old man with advanced prostate cancer is admitted to the emergency department with
mental obtundation. An electrolyte panel shows a serum calcium of 16.5 (normal 8.5-10.5
mg/dL). Which of the following therapies would be most useful in the management of severe
hypercalcemia?
(A)Acetazolamide plus saline infusion
(B)Furosemide plus saline infusion
(C)Hydrochlorothiazide plus saline infusion
(D)Mannitol plus saline infusion
109. Trimethoprim-sulfamethoxazole is established to be effective against which of the following
opportunistic infections in the AIDS patient?
(A)Cryptococcal meningitis
(B)Herpes simplex
(C)Toxoplasmosis
(D)Tuberculosis
112. Mr. Wu is a 71 year-old male who has worked as a painter for 50 years. He presented to his
primary care doctor with complaints of hematuria and urinary urgency. He was referred to a
urologist for cystoscopy. Office cystoscopy found a lesion in the bladder and he underwent a
subsequent TURBT (transurethral resection of the bladder tumor) that revealed Tis (in situ), nonmuscle invasive urothelial carcinoma (UC). What is the best treatment option for Mr. Wu?
(A) Intravesical Bacillus Calmette-Guerin (BCG)
(B) Intravesical Valrubicin
(C) Intravesical Mitomycin
(D) No therapy is needed at this time
113. LB is a 25 year-old female with AML day 24 s/p 7+3 induction (anthracycline plus cytarabine).
Her course has been complicated by culture negative febrile neutropenia with chest x-ray findings
(day 20) suggestive of pneumonia. She has received cefepime since day 20. She has been afebrile
for 72 hours and has now recovered her neutrophil count. Your leukemia team would like to know
when it would be appropriate to discontinue antibacterials. Which of the following is most
appropriate response?
(A) LB should stop cefepime since neutropenia has resolved and has been afebrile for at least 2
days
(B) LB has received an adequate course for pneumonia therefore cefepime can be discontinued
(C) LB has received an adequate course for pneumonia and cefepime can be switched to
levofloxacin prophylaxis
(D) LB has not received an adequate course for pneumonia but can be de-escalated to oral stepdown therapy to complete her treatment
124. What is the indication for the anti-VEGF drugs : Brolucizumab ?
(A) Dry Age-related Macular Degeneration
(B) Wet Age-related Macular Degeneration
(C) Metastatic colorectal cancer
(D) Cataract
125. What is the wrong statement about lithium?
(A) Nephrogenic diabetes insipidus is one of kidney toxicity in patients on chronic lithium
treatment.
(B) Lithium freely crosses the placenta labeled as pregnancy class D and has been implicated in
the increased risk of congenital cardiac defects, particularly the Ebstein anomaly.
(C) Lithium administration interfere in thyroid hormone synthesis and subsequent release,
resulting in hyperthyroidism.
(D) The kidneys treat lithium and sodium similarly which is the reason sodium depletion can
significantly elevate lithium reabsorption.
126. What is the right statement about "Clinical Practice Guidelines for the Prevention and
Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult
Patients in the ICU"?
(A) Sedative agent should be treated before pain control in critical ill.
(B) Analgesia-based sedation is usually a NSAID.
(C) The recent guidelines suggest that propofol or dexmedetomidine are preferable to either
midazolam or lorazepam in critically ill as light sedative agent.
(D) Morphine is the preffred pain control than fentanyl for those acute renal failure in ICU.
127. What is the worng statement for the hypoglycemic agent use ?
(A) Patient undergoing elective surgery, metformin should be withheld on the date of surgery.
(B) Patient undergoing elective surgery, empagliflozin must bePatient undergoing elective
surgery, empagliflozin must be stopped 3-4 days after surgery.
(C) Liraglutide is the choice for with diabetes with atherosclerotic cardiovascular disease .
(D) Canagliflozin is the choice for the patient wirh chronic kidney disease.
128. What is the correct symptom about the medication related adverse effect or overdose?
A. Morphine- miosis, B. Bupivacaine-seizure, C. Methimazole-agranulocytosis,
D. Cefoperazone/Sulbactam-ischemic event, (E) Amphotericin B-hyperkalemia,
F. Amphetamine-miosis, G. Trimethoprim/sulfamethoxazole-hyperkalemia.
(A) ABCG
(B) BDEF
(C) BCDG
(D) AEFG
130. 糖尿病降血糖藥物眾多，下列降血糖藥物中，實證研究顯示那些藥物，有明確可降低 Major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarctiomn,non-fatal stroke) 之結果? ( A ) Alpha-glucosidase inhibitors ( B ) Glucagon-like peptide 1 receptor agonists ( C ) Sulfonylurea ( D ) Dipepetidyl peptidase inhibitor ( E ) Sodium-glucose co-transporter-2 inhibitors (A) A+ C (B) B + D (C) A+ D (D) C+ E (E) B + E
135. A 6-year-old child (BW=17kg, body surface area= 0.9 m2
) is given a diagnosis of central diabetes
insipidus. Which is the most appropriatte initial treatment?
(A) Desmopressin
(B) Hydrocortisone
(C) fludrocortisone
(D) water restriction of no more than 900ml/day
136. A 6-year-old girl presents in shock. She has a past medical history significant for a dilated viral
cardiomyopathy with a baseline ejection fraction of 45%. Her current ejection fraction is 35%.
Her current blood pressure is 130/80 mmHg. Which is the most appropriate agent to use in this
child for cardiac support?
(A) Norepinephrine
(B) Milrinone
(C) Dopamine
(D) Phenylephrine
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