Many of the more important air pollutants, such as sulfur oxides, carbon monoxide, and nitrogen oxides, are found in nature. As the Earth developed, the concentrations of these pollutants were altered by various chemical reactions; they became components in biogeochemical cycle. These serve as an air purification scheme by allowing the compounds to move from the air to the water or soil on a global basis, nature's output of these compounds dwarfs that resulting from human activities. However, human production usually occurs in a localized area, such as a city. In this localized region, human output may be dominant and may temporarily overload the natural purification scheme of the cycle. The result is an increased concentration of noxious chemicals in the air. The concentrations at which the adverse effects appear will be greater than the concentrations that the pollutants would have in the absence of human activities. The actual concentration need not be large for a substance to be a pollutant; in fact, the numerical value tells us little until we know how much of an increase this represents over the concentration that would occur naturally in the area. For example, sulfur dioxide has detectable health effects at 0.08 parts per million (ppm), which is about 400 times its natural level. Carbon monoxide, however, has a natural level of 0.1 ppm and is not usually a pollutant until its level reaches about 15 ppm.