1. 肺腫瘤的治療選項,上皮生長因子接受體(EGFR,
epidermal growth factor receptor)的小分子抑制劑藥物
是重要的選擇。下列何種病人肺腫瘤有「EGFR突
變」的機率最高?
(A) A 35-year-old woman with a carcinoid tumor
(B) A 25-year-old man with a hamartoma
(C) A 75-year-old man with squamous cell carcinoma
and a history of asbestos exposure
(D) A 58-year-old man with a 100-pack-year history of
tobacco use with small-cell lung carcinoma
(E) A 54-year-old woman who has never smoked with
an adenocarcinoma
3. 一69歲男性,病理切片診斷確診罹患小細胞肺癌
(SCLC, small-cell lung cancer),PET/CT掃描結果顯
示右側肺門(hilar)部位有一4 x 5公分腫塊,且同側有
中等量(moderate)的肋膜積水,經肋膜積水穿刺檢
查,肋膜積水細胞學證實同樣有SCLC癌細胞。下列
敘述何者為真?
(A) Surgical therapy alone has a high curative rate for
his stage of SCLC
(B) Radiation plays no palliative role at all in therapy for
this disease
(C) Twenty percent of patients with SCLC are diagnosed
with the same stage of disease as this patient
(D) The majority of patients with SCLC of this stage
respond to chemotherapy alone and go into
remission with a very high 3-year survival
(E) This patient has extensive-stage disease
6. 一位31歲男性,若有下列理學檢查發現或家族病
史,會需要將「遺傳性非多發息肉性大腸癌」
(HNPCC,hereditary nonpolyposis colon cancer) 積極
列入篩檢(screening)的考慮?
(A) Innumerable polyps visualized on routine
colonoscopy
(B) Mucocutaneous pigmentation
(C) New diagnosis of ulcerative colitis
(D) {A}+{B}+{C} (E) Father, paternal uncle, and paternal cousin with
colon cancer diagnosed at age 50, 66, and 35 years,
respectively
10. 有關膽管癌(cholangiocarcinoma)的敘述,下列何者
並不正確?
(A) The incidence of cholangiocarcinoma has been
increasing in recent years
(B) Primary sclerosing cholangitis and hepatitis C virus
infection are associated with cholangiocarcinoma
(C) Most patients present due to an abnormal screening
ultrasound, without symptoms
(D) Asians infected with liver flukes have an increased
risk of cholangiocarcinoma
(E) Surgical resection may achieve 40% 5-year Survival
with an R0 resection