4. Eukaryotic RNA polymerase II required transcription factors for transcription. Which transcription factor can recognize a common promoter (TATA box)? Which transcription factor is responsible for phosphorylation on C-terminal domain of RNA polymerase II and what is the physiological meaning for such phosphorylation? (8%)

3. Why does liver damage cause jaundice? (5%)

2. High levels of cholesterol in the blood is positively correlated with the incidence of atherosclerosis. The ratio of LDL: HDL is a better indicator of coronary artery obstruction, Why? (6%)