59. Which of the following enzymes does NOT require tetrahyrobiopterin (BH4) as a cofactor? (A) Phenylalanine hydroxylase, which converts phenylalanine to tyrosine. (B) Tyrosine hydroxylase, which converts tyrosine to 3,4-dihydroxyphenylalanine (DOPA). (C) Tryptophan hydroxylase, which converts tryptophan to 5-hydroxytryptophan (5- HTP). (D) Nitrie oxide synthase (NOS), which eatalyzes the production of nitric oxide (NO). (E) 25-Hydroxylase, which converts cholecalciferol (vitamin D3) to 25- hydroxycholecalciferol

1. The Nobel Prize in Physiology or Medicine 2014 was awarded for discoveries concerning peripheral immune tolerance. Which of the following statements is NOT correct? (A) Peripheral immune tolerance mechanisms restrain self-reactive T cells that escape clonal deletion during thymic maturation. (B) Defects in peripheral immune tolerance may cause systemic lupus erythematosus. (C) CD4+CD25+ regulatory T cells contribute to the maintenance of peripheral immune tolerance. (D) FOXP3 is a master regulator of cytotoxic T cells that destroy self-reactive effector T cells. (E) Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) are caused by mutations in the FOXP3 gene.

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