複選題35. Which of the following statements about apoptosis is (are) CORRECT? (A) A set of core apoptotic proteins, including BCL-2, APAF, and Caspase 3, are conserved in all eukaryotes, including yeast (B) Apoptosis is mainly regulated by extrinsic signals, and intrinsic genetic mechanisms are generally not involved in most apoptosis (C) Immune cell gathering around the dying apoptotic cell is an important feature of apoptosis, which distinguishes it from necrosis (D) Failure of energy production in apoptotic cells exposes phosphoserine on the extracellular surface of plasma membrane, which signals the phagocytic cells to engulf the corpse of apoptotic cells (E) Triggers of apoptosis include lack of trophic factors, DNA damage and excessive cellular activity (e.g., glutamate excess triggers neuronal death)