試題詳解

36. The enzymes of fatty acid oxidation are located in the mitochondria matrix, so free fatty acids must be transported through the shuttle into the mitochondria. Which of the following statements regarding the shuttle is correct?
(A) Free fatty acid must be activated by a fatty acyl-CoA synthetase, through the hydrolysis of one high-energy bond in ATP, to yield a fatty acyl-CoA before entering the shuttle.
(B) The enzyme responsible for esterifying carnitine with acyl-CoA in both inner and outer mitochondria membranes is the rate-limiting step for oxidation.
(C) Coenzyme A in the cytosol is largely used in the oxidative degradation of fatty acids.
(D) This shuttle plays a crucial role in transporting medium-chain fatty acids into the mitochondria for beta-oxidation.
(E) Fatty acyl-CoA destined for mitochondria oxidation must be attached to carnitine to be shuttled across the inner mitochondria membrane.