複選題
56.下列對抗病毒藥物ganciclovir的敘述,何者錯誤?
(A)是guanosine 的核苷類似物(guanosine analogue)
(B)此藥物需要經由病毒的thymidine kinase磷酸化後才具有活性
(C)此藥物可以抑制RNA polymerase的功能
(D)可用來治療巨細胞病毒性視網膜炎(cytomegalovirus retinitis)
答案:登入後查看
統計: A(504), B(1192), C(1322), D(402), E(88) #1557886
統計: A(504), B(1192), C(1322), D(402), E(88) #1557886
詳解 (共 10 筆)
#3768102
(B)應該改成 經病毒的protein kinase活化
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#4156890
In cells infected by HSV-1 or HSV-2, TK catalyzes the phosphorylation of ganciclovir to ganciclovir monophosphate.

Because CMV lacks the gene for TK, the enzyme that catalyzes the initial phosphorylation of ganciclovir in CMV-infected cells is the phosphotransferase encoded by UL97 gene.

https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/ganciclovir\
http://jtp.taiwan-pharma.org.tw/097/108-112.html
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