115. 有關 phenytoin 之敘述，下列何者錯誤？
(A)眼球震顫及步態不穩為其副作用
(B)齒齦增生及多毛症為其副作用
(C)長期使用不會影響骨質
(D)其代謝為非線性藥動學

101. 目前糖尿病治療藥物中之針劑，除胰島素外，也有 GLP-1 receptor agonist 針劑藥物，與 DPP-4 inhibitors 均為 Incretin 類藥物。以下有關 Incretin 之敘述，何者為錯誤？ (A)GLP-1 可刺激胰島素分泌，抑制昇糖激素 (Glucagon)分泌 (B)使用 GLP-1 receptor agonist 治療糖尿病患者時，也有明顯減輕體重之效果 (C)第一型糖尿病患者也適用 GLP-1 receptor agonist (D)使用 GLP-1 receptor agonist 可降低糖尿病患之食慾及延緩未排空時間

102. 下列何者骨質疏鬆治療藥物的給藥頻率為每月一次? (A)Alendronate sodium tab (B)Zoledronic acid bot (Aclasta) (C)Ibandronate tab (D)Denosumab syringe

103. 下列何者最不可能是 amiodarone 造成之副作用？ (A)Hypothyroidism (B)Pulmonary fibrosis (C)Abnormal liver function (D)Hypokalemia

104. 有關合併症與高血壓治療首選之配對，下列何者正確？ (A)糖尿病(Diabetes Mellitus)－felodipine (B)上心室心搏過速（paroxysmal supraventricular tachycardia, PSVT）－losartan (C)冠狀動脈心臟疾病(coronary artery disease, CAD)－metoprolol (D)慢性腎臟疾病(chronic kidney disease, CKD)－diltiazem

105. A 45-year-old male stomach cancer patient underwent tumor removal surgery. After surgery, he developed megaloblastic anemia. His anemia is caused by a deficiency of X and can be treated with Y. (A)X = intrinsic factor； Y = folic acid. (B)X = intrinsic factor； Y = vitamin B12 (C)X = extrinsic factor； Y = parenteral iron (D)X = extrinsic factor； Y = sargramostim

106. Which of the following drugs has a high affinity for 5-HT2 receptors in the brain, does not cause extrapyramidal dysfunction or hematotoxicity, but is reported to increase the risk of significant QT prolongation? (A)Clozapine (B)Haloperidol (C)Valproic acid (D)Ziprasidone

107. A 40-year-old woman has sporadic attacks of intense anxiety with marked physical symptoms, including hyperventilation, tachycardia, and sweating. If she is diagnosed as suffering from a panic disorder, the most appropriate drug to use is (A)Alprazolam (B)Eszopiclone (C)Flurazepam (D)Ramelteon

108. A 62-year-old man with advanced prostate cancer is admitted to the emergency department with mental obtundation. An electrolyte panel shows a serum calcium of 16.5 (normal 8.5-10.5 mg/dL). Which of the following therapies would be most useful in the management of severe hypercalcemia? (A)Acetazolamide plus saline infusion (B)Furosemide plus saline infusion (C)Hydrochlorothiazide plus saline infusion (D)Mannitol plus saline infusion

109. Trimethoprim-sulfamethoxazole is established to be effective against which of the following opportunistic infections in the AIDS patient? (A)Cryptococcal meningitis (B)Herpes simplex (C)Toxoplasmosis (D)Tuberculosis

110. 38 歲男性，175 公分，108 公斤，無過去病史。因左下肢紅、腫、熱、痛而住院，診斷為深層靜脈血栓 (deep vein thrombosis, DVT)，入院後醫師立即以 heparin 治療，使用 heparin5 天後，醫師欲改為口服藥，下列何者最適當？ (A) aspirin 100 mg QD (B) cilostazol 100 mg BID (C) warfarin，international normalized ratio (INR)目標值 2.5～3.5 (D) edoxaban 60 mg QD

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