14 Theophylline 與下列何藥品併用時，會使 theophylline 代謝增加、血中濃度下降？
(A) Carbamazepine
(B) Ticlopidine
(C) Clarithromycin
(D) Enoxacin

答案：登入後查看
統計： A(673), B(11), C(59), D(6), E(0) #412553

詳解 (共 2 筆)

#837505
Carbamazepine may decrease theophylline serum levels. Also, theophyllines may decrease serum levels and effects of carbamazepine. The mechanisms may be related to induction of hepatic CYP450 metabolism.
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#1647094

↓ theophylline 代謝

↑

☄   Cimetidine

☄ Macrolides: Clarithromycin,  Erythromycin

☄ Quinolones:  Ciprofloxacin

☄  競爭CYP3A4代謝ticlopidine

☄   脂肪/ 糖類食物

☄   年紀 (<6 mos, 老人)

☄   左心室衰竭. 肝功能異常.肺炎

☄   Phenotoin

☄   Phenobarbital

☄   RIF

☄   Smoking (為CYP1A2誘導劑)

☄  抗癲癇藥

☄  抗結核藥


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