19 下列心肌收縮劑（inotropic agent），何者是 phosphodiesterase Ⅲ的抑制劑？
(A) Dobutamine
(B) Digoxigenin
(C) Milrinone
(D) Ouabain

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統計： A(26), B(25), C(324), D(19), E(0) #418125

詳解 (共 5 筆)

#1519947
Amrinone與Milrinone都是...
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#802723
Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the ß receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.
 
Milrinone, at relevant inotropic and vasorelaxant concentrations, is a selective inhibitor of peak III cAMP phosphodiesterase isozyme in cardiac and vascular muscle.
Milrinone is not a beta-adrenergic agonist nor does it inhibit sodium-potassium adenosine triphosphatase activity as do the digitalis glycosides.
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#802725
This inhibitory action is consistent with cAMP mediated increases in intracellular ionized calcium and contractile force in cardiac muscle, as well as with cAMP dependent contractile protein phosphorylation and relaxation in vascular muscle.
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#3387049
(A) Dobutamine : bet...
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#5737026
PDE3 :  存在心臟及血管平滑肌的 ...
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