阿摩線上測驗
22 下列強心劑何者是藉由抑制 phosphodiesterase 來達到強心作用？
(A) Milrinone
(B) Digoxin
(C) Dobutamine
(D) Dopamine
統計： A(894), B(108), C(92), D(15), E(0) #453868
詳解 (共 6 筆)
Milrinone為PDE3抑制劑。會增加細胞內cAMP的濃度，造成細胞內Ca2+增加，心臟收縮力增強。
Milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.
Milrinone is used as a short-term treatment for treat life-threatening heart failure.
Inotropic agent
Inotropic agents affect the contraction of the heart muscle. Positive inotropes stimulate and increase the strength of heart muscle contraction causing the heart rate to increase. Negative inotropic agents weaken the force of muscular contractions.
Inotropic state depends on the amount of calcium in the cytoplasm of the heart muscle wall, as contractility of the heart depends on control of intracellular calcium i.e. control of calcium entry into the cell membrane and calcium storage in the sarcoplasmic reticulum. The main factors controlling calcium entry are activity of voltage gated calcium channels and sodium ions, which affects calcium/sodium ion exchange.
| 藥物 |
Milrinone
（仍在使用）
|
Inamrinone
（已下市）
|
| 機轉 | PDE 3 抑制劑 | |
| 適應症 |
IV 短期治療
急性心衰竭
|
|
| 結構 | bipyridine | |
| 藥效強度 |
Milrinone 約比 Inamrinone 強 10-75 倍
|
|
| 代謝 |
83% 原型腎排除
|
- |
| 排除半衰期 | 2 hr | 4 hr |
| 血液副作用 | - |
血小板減少症 (Thrombocytopenia)
|
| 其他備註 |
不可與furosemide同時使用
（化學結構不相容）
|
|
