32.乾癬（psoriasis）病人較常出現下列何種基因？
(A)HLA-A2
(B)HLA-B27
(C)HLA-Cw*06
(D)HLA-DR4

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統計： A(29), B(149), C(355), D(127), E(0) #2625787

詳解 (共 2 筆)

#5145381
(A) HLA-A2：Hodgkin...


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Based on current data, within PSORS1, HLA-Cw6 is the allele most likely to be associated with psoriasis susceptibility. The role of HLA-Cw6 in the pathogenesis of Ps is not fully understood, but its involvement in innate and acquired immunity mechanisms is indicated. 
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The prevalence of the HLA-Cw6 allele in the general population varies from 14.1% to 59.1%. In the Ps population, the percentage of patients with the presence of HLA-Cw6 varies from 10.5% to 77.2% [5]. The presence of HLA-Cw6 in patients with Ps is more frequently found in Caucasian patients than in the Asian population [4, 5]. The differences in the presence of HLA-Cw6 observed in the studies may be attributed to small sample size and ethnic diversity.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661405/
Owczarek W. The role of HLA-Cw6 in psoriasis and psoriatic arthritis. Reumatologia. 2022;60(5):303-305.
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