33.A 58-year-old man with a long history of chronic hepatitis B develops a 4-cm mass in the liver. Biopsy shows of malignant chronic hepatocytes forming trabeculae and pseudoacini.Which mechanism best explains the inflammation in this patient's neoplasm?

(A) Creation of a microenvironment that completely prevents apoptosis
(B) Direct viral integration always activating the same proto-oncogene
(C) Increased reactive oxygen speciess causing causing DNA damage and promoting genomic instability
(D) Exclusive inactivation of tumor suppressor genes without affecting oncogenes