試題詳解

39. Regarding the neuron–glial interactions within the spinal cord after peripheral nerve injury (PNI), which of the following statement is least likely:
(A) Up-regulated P2X4R expression is induced in microglia within the spinal cord by PNI.
(B) In this P2X4R+ state, microglia release BDNF, which inhibits neurons in the spinal nociceptive processing network.
(C) Minocycline and propentofylline is glial-specific inhibitors.
(D) MAPKs, p38, is the intracellular mediator of P2X4R–BDNF signaling in microglia-mediated post–nerve injury pain states.
(E) BDNF from microglia is a critical signaling molecule mediating the central pathophysiological effects of PNI.