44 王先生一個月前經歷了急性心肌梗塞併發心臟衰竭,目前使用 simvastatin, aspirin, indapamide 及lisinopril,近因關節炎發作,服用 2 週的 naproxen。今天發現 BUN:66 mg/dL, SrCr:2.2 mg/dL。下列何項因素最可能造成他的急性腎臟衰竭?
(A)一個月前的心肌梗塞
(B)心臟衰竭及 SrCr 過高
(C)已經服藥一個月的 lisinopril
(D) Naproxen 及心臟衰竭的問題
答案:登入後查看
統計: A(6), B(94), C(107), D(1267), E(0) #411395
統計: A(6), B(94), C(107), D(1267), E(0) #411395
詳解 (共 7 筆)
#2323903
回樓上,以下我猜想 XD
ACEI 對腎動脈狹窄者,會引起腎衰竭 (但題目沒提到)
不然他其實還算可以保護腎臟(減少蛋白尿
而NSAIDS的話,會使腎絲球入球小動脈收縮,減少灌流,再遇上HF,比較容易導致急性腎衰
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#790005
Naproxen 抑制COX使prostagalndins減少及使腎臟血流減少
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#4071616
An increase in SCr of up to 30% is expected in the first two to five days of therapy with an ACE inhibitor. This effect will stabilize after a few weeks of therapy and remain until discontinuation of the drug.5 Treatment with an ACE inhibitor should be stopped if SCr increases by more than 30% and reduced if reinitiated. A mild decrease in renal function due to ACE inhibitors is acceptable due to the benefits that result from long-term therapy. |
Howell, H. R., M. L. Brundige, and L. Langworthy. "Drug-induced acute renal failure." US PHARMACIST 32.3 (2007): 45.
都已經使用一個月了,沒事就是沒事。
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