45.A 54-year-old woman presents with a persistent nonproductive cough and progressive dyspnea. Highresolution CT shows bilateral, predominantly subpleural reticular opacities and honeycomb changes,
greatest at the lung bases. Surgical lung biopsy reveals patchy interstitial fibrosis with areas of normal
lung alternating with dense scarring and fibroblastic foci. Which of the following is the most
appropriate diagnosis?

(A) Hypersensitivity pneumonitis

(B) Nonspecific interstitial pneumonia (NSIP)
(C) Cryptogenic organizing pneumonia

(D) Usual interstitial pneumonia (UIP) pattern of idiopathic pulmonary fibrosis