阿摩線上測驗
47.藥癮愛滋感染者同時接受抗愛滋病毒藥品及methadone替代治療時，下列敘述何者錯誤？
(A)lamivudine會誘發CYP3A4的活性，使methadone濃度下降，病人可能出現戒斷症狀
(B)saquinavir會抑制CYP3A4活性，使methadone的作用時間加長
(C)methadone經由CYP3A4代謝，與protease inhibitors類抗愛滋病毒藥品會有不等程度的交互作用
(D)methadone會增加zidovudine的血中濃度及副作用
統計： A(2794), B(291), C(264), D(1341), E(0) #1631377
詳解 (共 10 筆)
由於有限的代謝率及血漿蛋白之結合率，且幾乎以原態完全經由腎臟排除，故lamivudinen代謝性的交互作用很少。
Methadone: 由CYP3A4代謝
lamivudine/zidovudine: CYP3A4受質
UpToDate
Methadone may enhance the QTc-prolonging effect of Saquinavir. Saquinavir may decrease the serum concentration of Methadone.
The mechanism of this interaction is uncertain. AUC changes reported with saquinavir / ritonavir are close to those reported with ritonavir alone at similar doses,6,7,8 so the role of saquinavir in the interactions is questionable. Ritonavir could theoretically induce methadone metabolism, particularly via CYP2B6.9
