47. Statins are a class of drugs that lower cholesterol. They are typically prescribed to people who are at high risk of cardiovascular disease. What is the secondary and long-term therapeutic effect of statins on cholesterol levels? (A) They increase the degradation of the LDL receptor. (B) They tend to bind to the cholesterol through a single proteolytic cleavage by a matrix metalloproteinase. (C) They trigger the activation of SREBP, leading to increased expression of LDL receptors. (D) They inhibit the transport of citrate out of the mitochondria. (E) They prevent the binding of Insig to SCAP regardless of cholesterol levels.