試題詳解

49某藥物遵循單室模式藥動學且由血漿進行肝代謝(metabolism,km= 0.200 hr-1)、腎排泄(kidney excretion, ke=0.250 hr-1)、排泄(biliary excretion, kb= 0.150 hr-1)，試問正常及非腎排泄的排除半衰期(elimination half-life)分別爲多少小時？
(A) 0.693/(0.20+0.25+0.15)及 0.693/(0.20+0.15)
(B) 0.693/(0.25+0.15)及 0.693/(0.20+0.25)
(C) 0.693/(0.20+0.25)及0.693/(0.25+0.15)
(D) 0.693/(0.20+0.25+0.15)及 0.693/(0.25+0.15)