50 醫師欲使用isoniazid、rifampin、ethambutol、py..-阿摩線上測驗

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50 醫師欲使用isoniazid、rifampin、ethambutol、pyrazinamide 來治療 65 歲、身高155 公分、體重48 公斤之女性肺結核病患 (tuberculosis) 。她的血中肌胺酸酐 (serum creatinine) 值為 4.0 mg/dL ，ALT (alanine aminotransferase)、AST (aspartate aminotransferase) 分別為10 與15 U/L，請問上述四種藥品那些需要調整劑量？
(A) 病人肝、腎功能都正常，四種藥都不需調整劑量
(B) 病人腎功能不佳，四種藥都要調整劑量
(C) 病人腎功能不佳，ethambutol、pyrazinamide 要調整劑量
(D) 病人肝功能不佳，isoniazid、rifampin 要調整劑量

專技 - 調劑學與臨床藥學- 92 年 - 92-1 專技高考_藥師：調劑學（包括臨床藥學與治療學）#10633

答案：C
難度： 簡單

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	1F Bryan 國三上 (2014/05/13) Isoniazin、rifampin 肝毒性，ethambutol,pyriainamide 腎毒性檢舉
	2F Bryan 國三上 (2014/05/15) ethambutol 經肝臟代謝為aldehyde 及 dibutyric acid (非活性) 經尿液排出(以原型藥 , 8~15%以代謝產物形式) 檢舉
	3F 我愛阿摩，阿摩愛我 (2014/06/14) Normal levels of creatinine in the blood are approximately 0.6 to 1.2 mg/dL in adult males and 0.5 to 1.1 mg/dL in adult females. Creatinine levels that reach 2.0 or more in babies and 10.0 or more in adults may indicate severe kidney impairment Alanine aminotransferase1Males:10–40 units per liter (U/L) or 0.17–0.68 microkats per liter (mckat/L)Females:7–35 U/L or 0.12–0.60 mckat/LAspartate aminotransferase (AST)1Males:14–20 units per liter (U/L) or 0.23–0.33 microkats per liter (mckat/L)Females:10–36 U/L or 0.17–0.60 mckat/... 查看完整內容 Normal levels of creatinine in the blood are approximately 0.6 to 1.2 mg/dL in adult males and 0.5 to 1.1 mg/dL in adult females. Creatinine levels that reach 2.0 or more in babies and 10.0 or more in adults may indicate severe kidney impairment Alanine aminotransferase1Males:10–40 units per liter (U/L) or 0.17–0.68 microkats per liter (mckat/L)Females:7–35 U/L or 0.12–0.60 mckat/LAspartate aminotransferase (AST)1Males:14–20 units per liter (U/L) or 0.23–0.33 microkats per liter (mckat/L)Females:10–36 U/L or 0.17–0.60 mckat/L 檢舉

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50 醫師欲使用isoniazid、rifampin、ethambutol、py..-阿摩線上測驗

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