(A) Alendronate 錠劑 會帶電 不易吸收 (B) Itraconazole 膠囊 平常很難溶 遇酸還比較好溶一點(汗 Itraconazole is a very weak base (pKa = 3.7), is ionized at a low pH such as in gastric secretion, and is highly lipophilic being practically insoluble in water and in dilute acid solutions. (C) Nicotine 口含錠 遇酸會變帶兩個正電 不易被吸收 Nicotine is a weak base with a pKa of 8.0. In its ionized state, such as in acidic environments, nicotine does not rapidly cross membranes. (D)rabeprazole : 是一種PPI 如果遇酸就代表到胃啦 那就會變成活性態 喝酸的會提早變活性態 吸收會下降 It is a prodrug - in the ...
(A) Alendronate 錠劑 會帶電 不易吸收 (B) Itraconazole 膠囊 平常很難溶 遇酸還比較好溶一點(汗 Itraconazole is a very weak base (pKa = 3.7), is ionized at a low pH such as in gastric secretion, and is highly lipophilic being practically insoluble in water and in dilute acid solutions. (C) Nicotine 口含錠 遇酸會變帶兩個正電 不易被吸收 Nicotine is a weak base with a pKa of 8.0. In its ionized state, such as in acidic environments, nicotine does not rapidly cross membranes. (D)rabeprazole : 是一種PPI 如果遇酸就代表到胃啦 那就會變成活性態 喝酸的會提早變活性態 吸收會下降 It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form.
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