55 下列藥品配對中，何者會產生藥效學交互作用（Pharmacodynamic interaction）？
(A) Hydrochlorothiazide, lithium
(B) Fluoxetine, theophylline
(C) Cimetidine, warfarin
(D) Digoxin, verapamil

答案：登入後查看
統計： A(500), B(141), C(137), D(832), E(0) #414777

詳解 (共 4 筆)

#892647
(A) Hydrochlorothiazide, lithium ：利尿劑會減少鋰的排泄，產生藥動學交互作用。
(B) Fluoxetine, theophylline ：Fluoxetine會減少茶鹼的代謝，產生藥動學交互作用。
(C) Cimetidine, warfarin ：Cimetidine會減少warfarin的代謝，產生藥動學交互作用。
(D) Digoxin, verapamil：兩者合併使用，會加重心跳減慢，產生藥效學交互作用。
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#1431341
(D)
併用會加重心跳減慢→藥效學
抑制PG醣蛋白→藥動學
64
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#1426216
verapamil 抑制 p糖蛋白 不算是藥動學嗎？？？？求解
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#892649
Verapamil increases digoxin levels significantly in most patients. Verapamil decreases renal and extrarenal clearance of digoxin. Serum digoxin levels may increase by 50% to 75% during the first week of concomitant verapamil therapy. Increases may be larger in patients with hepatic cirrhosis. Digoxin and verapamil have additive effects in slowing AV conduction. In clinical trials with digitalized patients with atrial fibrillation or atrial flutter, 15% of patients developed ventricular rates of less than 50/min and 5% developed asymptomatic hypotension. 
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