試題詳解

55. Which of the following statements about IgA nephropathy (IgAN) is INCORRECT?
(A) Dominant or codominant IgA mesangial staining is essential for diagnosis.
(B)Antigenic galactose-deficient IgA1 plays a central role in the pathogenesis of IgAN. IgG or IgA autoantibodies form immune complexes with aberrantly galactosylated IgA1 leading to glomerular deposition.
(C)The parameters in Oxford classification of IgAN include mesangial hypercellularity (M), endocapillary hypercellularity( E ), segmental sclerosis (S), interstitial fibrosis/tubular atrophy (T) and crescents ( C ).
(D)Henoch-Schönlein purpura also has glomerular mesangial IgA deposition, and can be distinguished from IgAN by renal biopsy.