56 就懷孕婦女而言,下列那些藥品為禁忌?①ampicillin ②heparin ③misoprostol ④ribavirin
(A)①③
(B)①④
(C)②③
(D)③④
統計: A(82), B(18), C(58), D(1151), E(0) #415018
詳解 (共 5 筆)
(D)ribavirin 會致畸胎,孕婦禁用
| Heparin | Warfarin | Lithium | |
| 孕 | O | X | O |
| 哺 | O | O | X |

Ribavarin 不可用在懷孕或準備懷孕婦女,from 仿單
Results: The registry enrolled 280 pregnancies resulting in 186 live births: eight birth defect cases among 88 directly exposed [9.09% (8/88, 95% CI: 4.01, 17.13)], and six birth defect cases among 98 indirectly exposed [6.12% (6/98, 95% CI: 2.28, 12.85)]. The 95% CI around the birth defect rate among directly exposed pregnancies exceeds the MACDP rate; however, no patterns suggestive of a teratogenic mechanism or safety signal were detected.
Conclusion: Based on the patterns of birth defects reported, the final results from this registry do not suggest a clear signal of human teratogenicity for ribavirin. The registry did not meet sample size requirements; therefore, caution should be exercised when interpreting the results.
From: Sinclair SM, Jones JK, Miller RK, Greene MF, Kwo PY, Maddrey WC. Final results from the ribavirin pregnancy registry, 2004-2020. Birth Defects Res. 2022 Dec 1;114(20):1376-1391. doi: 10.1002/bdr2.2094. Epub 2022 Oct 28. PMID: 36305304.