63.下列各藥品於療劑監測時之血中濃度範圍建議值，何者最適當？
(A)gentamicin波峰（peak）：0.5~2 μg/mL
(B)phenytoin：0.5~2 ng/mL
(C)theophylline：5~15 μg/mL
(D)valproic acid波谷（trough）：5~10 μg/mL

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統計： A(90), B(88), C(2599), D(134), E(0) #537454

詳解 (共 6 筆)

#1010516
(A)gentamicin：波峰（pea...
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#2902682

最佳解的gentamicin 的peak，應該是8~10 μg/ml，trough為1~2  μg/ml。

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#2306241
Aminoglycoside : pea...
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#3430054

gentamicin 

Therapeutic levels

Peak:

Sepsis, pneumonia, other serious infections: 6 to 8 mcg/mL (Matzke 1983)

Life-threatening infections: 8 to 10 mcg/mL (Zaske 1986)

Urinary tract infections, including pyelonephritis: 4 to 6 mcg/mL (Matzke 1983)

Synergy against gram-positive organisms: 3 to 4 mcg/mL (AHA [Baddour 2015])

Trough:

Serious infections: 0.5 to 1 mcg/mL (Zaske 1986)

Life-threatening infections: 1 to 2 mcg/mL (Zaske 1986)

Synergy against gram-positive organisms: <1 mcg/mL (AHA [Baddour 2015])


Reference Uptodate

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#3483349
  • Gentamicin：μg/mL
    • MDD
      • 1.7 mg/kg
      • 谷< 2；峰< 12
    • EID
      • 7 mg/kg
      • 谷< 0.5；峰16~24
    • TDM抽血時機: Peak輸注30min完成後30min，Trough下次給藥前
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