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Ketoconazole也會造成酒精代謝不良

[Uptodate Drug Interactions]

Title Alcohol (Ethyl) / Ketoconazole (Systemic)

Risk Rating D: Consider therapy modification

Summary Ketoconazole (Systemic) may enhance the adverse/toxic effect of Alcohol (Ethyl). 

Severity Major 

Reliability Rating Fair 

Patient Management Advise patients to avoid alcohol ingestion while taking ketoconazole. The prescribing information for ketoconazole warns against concurrent use due to both a potential increase in the risk for hepatotoxicity and for the possibility of a disulfiram-like reaction.

Discussion Ket...

Ketoconazole也會造成酒精代謝不良

[Uptodate Drug Interactions]

Title Alcohol (Ethyl) / Ketoconazole (Systemic)

Risk Rating D: Consider therapy modification

Summary Ketoconazole (Systemic) may enhance the adverse/toxic effect of Alcohol (Ethyl). 

Severity Major 

Reliability Rating Fair 

Patient Management Advise patients to avoid alcohol ingestion while taking ketoconazole. The prescribing information for ketoconazole warns against concurrent use due to both a potential increase in the risk for hepatotoxicity and for the possibility of a disulfiram-like reaction.

Discussion Ketoconazole prescribing information notes that rare cases of a ketoconazole/alcohol interaction resulting in a disulfiram-like reaction have been reported.1,2 The reactions were reportedly characterized by flushing, rash, peripheral edema, nausea, and headache that resolved within hours. Additionally, two separate case reports describing patients who experienced an intolerance to alcohol while taking oral ketoconazole 200 mg daily have been published.3,4 The exact mechanism for this reported interaction is uncertain.

In addition, the ketoconazole prescribing information recommends that patients not consume alcohol while taking ketoconazole.1,2 This warning appears to be largely due to the potential for both ketoconazole and alcohol to cause hepatic toxicity.