70 李先生長期服用 phenelzine 治療精神疾患，因自行服用含 ephedrine 之感冒藥，導致頭痛、血壓上升。此現象極有可能是兩藥品間之何種作用造成的？
(A) Phenelzine 增加 ephedrine 的生體可用率
(B) Phenelzine 與 ephedrine 競爭相同蛋白結合位置
(C) Phenelzine 抑制 ephedrine 的代謝
(D) Phenelzine 與 ephedrine 競爭從泌尿道之排除

答案：登入後查看
統計： A(18), B(75), C(293), D(23), E(0) #417544

詳解 (共 2 筆)

#865959

MAO inhibitors
Isocarboxazid
Phenelzine (Nardil)
Selegiline (Eldepryland others)
Tranylcypromine (Parnate)

Sympathomimetics:
Dopamine
Ephedrine
Isometheptene mucate
Mephentermine
Metaraminol
Phenylephrine
Pseudoephedrine

Increased risk of hypertensive crisis due to increased norephinephrine availability

  • Avoid combination therapy
  • If combination therapy is required, monitor blood pressure and for frequent headaches or palpitations
  • If hypertensive crisis occurs, discontinue MAO inhibitor therapy and administer phentolamine 5 mg slow intravenous push to lower blood pressure
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#6544585
Phenelzine： 非選擇性、不可逆...
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