70.Digoxin與下列何者併用時,無須調降digoxin劑量?
(A)amiodarone
(B)quinidine
(C)rifampin
(D)verapamil
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統計: A(151), B(208), C(4604), D(460), E(0) #1541410
統計: A(151), B(208), C(4604), D(460), E(0) #1541410
詳解 (共 7 筆)
#2294658
(C)RIFAMPIN增加肝酵素代謝 但digoxin不是肝代 所以下降跟肝代沒有關係 micromedex交互作用↓20%digo level 作用 未知
不要沒查就亂回答喔~
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#3465643
DDI- Rifampin & Digoxin
Micromedex: (major, good)
Probable mechanism unknown
UpToDate: (moderate, fair)
P-glycoprotein/ABCB1 Inducers may decrease the serum concentration of P-glycoprotein/ABCB1 Substrates. P-glycoprotein inducers may also further limit the distribution of p-glycoprotein substrates to specific cells/tissues/organs where p-glycoprotein is present in large amounts (e.g., brain, T-lymphocytes, testes, etc.).
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1