73.周女士61歲，無任何慢性疾病，一個月前發現乳房異常腫塊，粗針抽吸檢查結果顯示：left breast，infiltrating ductal carcinoma，ER/PR negative，HER2/neu overexpression 3+，nuclear grade 3。此病人可以使用下列何種藥品治療？
(A)Tamoxifen
(B)Letrozole
(C)Trastuzumab
(D)Leuprolide

答案：登入後查看
統計： A(208), B(14), C(1667), D(13), E(0) #411184

詳解 (共 7 筆)

#2348236

Trastuzumab 

女生看到糖，心臟就很挫怕得乳癌

作用目標:HER2 (女生)

不可用D5W稀釋 (糖)

副作用:CHF、心毒性 

Trastuzumab  Tra(挫)

適應症:乳癌


補充

單株抗體 未立即使用須冷藏

有效28天內

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#1046338
ER/PR negative: 動情激素接受體(ER)、黃體激素接受體(PR) negative，表明使用荷爾蒙拮抗劑效果不佳。
45
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#1425594
55.周女士61歲，無任何慢性疾病，病理報告顯示：ER/PR negative，HER2/neu overexpression3+，nuclear grade 3，診斷為infiltrating ductal carcinoma第二期，經過手術 切除，有關後續治療的選擇，下列何者錯誤？ 
(A)Doxorubicin + trastuzumab 
(B)Doxorubicin + cyclophosphamide 
(C)Docetaxel + trastuzumab 
(D)Docetaxel + cyclophosphamide
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#2491364
1.ER/PR negative: 動情...
(共 139 字，隱藏中）
前往觀看
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#1004529
在原發性乳癌病人中，有25％~30％其癌細胞HER2基因有過度表現的現象；這些乳癌患者比無HER2（(human epidermal growth factor receptor 2 protein；HER2 protein)） 過度表現患者，預後較差，對荷爾蒙治療或傳統CMF(Cyclophosphamide、Methotrexate、Fluorouracil)化學治療的效果也較差，復發機率相對較高病人存活時間也較短。

Trastuzumab是由DNA基因重組技術製成的人化單株抗體(humanized monoclonal antibody)，可對抗HER2基因高表現型之人化單株抗體。2000年衛生署核准上市。

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#1195178
(D)Leuprolide:常與男性賀爾蒙抑制劑併用以治療前列腺癌？
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#5501378

Leuprolide
機轉
Leuprolide is an agonist of gonadotropin releasing hormone (GnRH) receptors. Acting as a potent inhibitor of gonadotropin secretion, leuprolide produces an initial increase in luteinizing hormone (LH) and follicle stimulating hormone (FSH), which leads to a transient increase (5 to 12 days) in testosterone and dihydrotestosterone (in males) and estrone and estradione (in premenopausal females). Continuous leuprolide administration then results in suppression of ovarian and testicular steroidogenesis due to decreased levels of LH and FSH with subsequent decrease in testosterone (male) and estrogen (female) levels. In males, testosterone levels are reduced to below castrate levels. Leuprolide may also have a direct inhibitory effect on the testes, and act by a different mechanism not directly related to reduction in serum testosterone.

<Labeled Indications>
Central precocious puberty中樞性性早熟 
Endometriosis子宮內膜異位
Prostate cancer, advanced 攝護腺癌
Uterine leiomyomata (fibroids)子宮肌瘤

ref: uptodate

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