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76. 下列那一種抗憂鬱藥物，可以透過阻斷α2-腎上腺素型受體的作用方式，來增加腦中的腎上腺素性及血清素性神經傳遞作用？
(A) Bupropion
(B) Mirtazapine
(C) Imipramine
(D) Fluoxetine

專技 - 藥理學與藥物化學- 92 年 - 92-2 專技檢覈_藥師：生藥學及藥理學#15073

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	3F Bryan 國三上 (2014/04/26) Mirtazapine is a potent antagonist of 5-HT2 and 5-HT3 receptors. Mirtazapine has no significant affinity for the 5-HT1A and 5-HT1B receptors. Mirtazapine is a potent antagonist of histamine (H1) receptors, a property that may explain its prominent sedative effects. Mirtazapine is a moderate peripheral α1-adrenergic antagonist, a property that may explain the occasional orthostatic hypotension reported in association with its use. Mirtazapine is a moderate antagonist at muscarinic receptors, a property that may explain the relatively low incidence of anticholinergic side effects associated with i... 查看完整內容 Mirtazapine is a potent antagonist of 5-HT2 and 5-HT3 receptors. Mirtazapine has no significant affinity for the 5-HT1A and 5-HT1B receptors. Mirtazapine is a potent antagonist of histamine (H1) receptors, a property that may explain its prominent sedative effects. Mirtazapine is a moderate peripheral α1-adrenergic antagonist, a property that may explain the occasional orthostatic hypotension reported in association with its use. Mirtazapine is a moderate antagonist at muscarinic receptors, a property that may explain the relatively low incidence of anticholinergic side effects associated with its use. 檢舉
	4F 孟大二下 (2021/05/03) Mirtazapine為一 NaSSA(Norepinephrine and Specific Serotonergic 能阻斷 5-HT2與 α2-腎上腺性受器它也是鎮靜劑。檢舉
	5F 菜餅大三上 (2024/03/20) Mirtazapine：屬於 piperazinodibenzazepine 四環骨架之抗憂鬱藥，為 mianserin之等價異構物，以 pyridine 環取代苯環可使藥物之極性增加，使親脂性及鹼性下降，而使對 NET之抑制作用下降。可經由阻斷中樞突觸前a2-受體，促使NE與5-HT釋出，而增強中樞的交感活性，可歸屬在 NaSSA 類。檢舉

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