78 下列那些藥品與 paroxetine 併用，可能引起嚴重不良反應？① morphine ② meperidine ③ codeine ④ tramadol
(A)①②
(B)①④
(C)②③
(D)②④

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統計： A(23), B(27), C(59), D(181), E(0) #418004

詳解 (共 4 筆)

#1426981
【藥物交互作用易引起serotonin syndrome】
抗憂鬱藥：SSRI、SNRI、MAOI、Trazodone、Buspirone
解痙攣：Valproate
止痛劑：Meperidine、Tramadol、Pentazocine、Fentanyl（並不是所有Morphine-like都會 !!)
止咳劑：Dextromethorphan
抗偏頭痛：Sumatriptan
抗生素：Linzolid
抗病毒：Ritonavir
毒品：MDMA、LSD
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#1018082
paroxetine + tramadol ==> 導致serotonin syndrome 
paroxetine + meperidine ==> 導致serotonin syndrome
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#3479588

③ codeine：CYP2D6受質，用CYP2D6抑制劑反而沒辦法代謝，無法發揮藥效。

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#810399
Pharmacokinetically, coadministration with certain SSRIs, namely fluoxetine, paroxetine and possibly sertraline, may decrease the plasma concentrations of the active O-demethylated (M1) metabolite of tramadol due to inhibition of CYP450 2D6, the isoenzyme responsible for the formation of the metabolite.
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