一、Please translate the following paragraph into English.（10 分） 

 申請發明專利時，由專利申請權人備具申請書、說明書、申請專利範圍、摘要及必 要之圖式，向專利專責機關申請。以申請書、說明書、申請專利範圍及必要之圖式 齊備之日為發明專利申請日。

二、Write a composition entitled: “The latest amendment of Taiwan’s Patent Act dated at June 11, 2013” in English, please write at least 80 words.（20 分）

三、Please use 40 to 80 words to summarize the following article in English, do not copy any sentence in the excerpt.（20 分）  Last February during his Fireside Hangout, President Obama explained that patent trolls (known more formally as Patent Assertion Entities, or PAEs) “don’t actually produce anything themselves. They’re just trying to essentially leverage and hijack somebody else’s idea and see if they can extort some money out of them.” This type of abusive patent litigation is a major problem.  It’s also important to know what we’re not talking about here. We aren’t trying to make it harder to pursue legitimate intellectual property rights, or vigorously defend valid patents. Indeed, the United States has the best intellectual property protections in the world, and our system rightly ensures that these innovators are compensated for their creativity. The problem is when rogue companies make a business model out of exploiting and abusing the system, using it not to protect invention but to bring frivolous lawsuits to extract settlements from companies trying to serve American consumers. Bad patents in the system (such as those issued with broad or vague language) only compound the problem, and the issue extends far beyond any one industry. 

⑴Terbinafine

⑵Sildenafil

⑶Rosiglitazone

⑷Denosumab

二、試述合併使用 sulfonamides 和 trimethoprim 之作用機制和優點。（4 分）

⑴Hydrochlorothiazide

⑵Captopril

⑶Prazosin

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