申論題

特性：

1.可延緩藥物釋出，直至通過胃部

2.理想之材料為弱酸性高分子聚合物， pKa約為6

3.釋離機轉：pH值變化、酵素、與胃腸道液體接觸、藥品質粒計算

目的：

1.防止藥品受胃酸、胃內酵素破壞

2.防止藥品對胃黏膜產生刺激

3.防止嘔吐

4.欲於小腸達到局部高濃度

包衣配方：CAP、蟲膠、蜂蠟、脂肪酸

Ansel 原文書

Enteric-coated tablets have delayed-release features. They are designed to pass unchanged through the stomach to the intestines, where the tablets disintegrate and allow drug dissolution and absorption and/or effect. Enteric coatings are employed when the drug substance is destroyed by gastric acid or is particularly irritating to the gastric mucosa or when bypass of the stomach substantially enhances drug absorption. Examples include Ecotrin tablets and caplets (GlaxoSmithKline Beecham).